Clozapine: Indications, Precautions, and Monitoring


Antipsychotics are used to relieve the symptoms experienced during psychosis such as hallucinations, delusions or abnormal behaviour. Clozapine is an antipsychotic used for patients who have treatment resistant schizophrenia.

This short module provides an overview of what Clozapine is and its use in the treatment of psychosis. The use of Clozapine is restricted due to its unique adverse profile, and this module will discuss the contraindications, precautions and adverse effects.

This module will then discuss the dosages and monitoring requirements for people prescribed clozapine and action to take based on monitoring outcomes.

This module is suitable for any healthcare practitioner providing care to a patient prescribed clozapine.

Learning Objectives

At the end of this module participants will be able to:

  • Explain the indications for prescribing Clozapine.
  • Know the monitoring requirements.
  • Know what actions to take based on monitoring outcomes.
  • Describe the risks, contraindications and precautions in the use of Clozapine

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